Starling's Law at Small Scale: Surprising Sub-Cellular Adaptation of Cargo. Brian Maranville,; Kun Huang,; Angel E. Hollywood movie in hindi. Garcia,; Stephanie Tristram-Nagle. Kim,; Igor Dikiy,; David Posson,; David Eliezer,; Crina M.

• Ca' Foscari University of Venice • Cagliari State University • Free University of Bolzano • Politecnico di Bari • Scuola Superiore Sant'Anna • University of Bologna • University of Camerino • University of Genoa • University of Messina • University of Naples Federico II • University of Padova • University of Palermo • University of Parma • University of Pavia • University of Perugia • University of Pisa • University of Roma TRE • University of Rome Tor Vergata • University of Salerno • University of Siena • University of Verona.

Most of the proteins that are used in mitochondria are imported through the double membrane of the organelle. The information that guides the protein to mitochondria is contained in its sequence and structure, although no direct evidence can be obtained. In this article, discriminant analysis has been performed with 47 parameters and a large set of mitochondrial proteins extracted from the SwissProt database. A computational method that facilitates the analysis and objective prediction of mitochondrially imported proteins has been developed. If only the amino acid sequence is considered, 75–97% of the mitochondrial proteins studied have been predicted to be imported into mitochondria. Moreover, the existence of mitochondrial‐targeting sequences is predicted in 76–94% of the analyzed mitochondrial precursor proteins.

As a practical application, the number of unknown yeast open reading frames that might be mitochondrial proteins has been predicted, which revealed that many of them are clustered.